The Nutricia Learning Center features tools and educational resources for Metabolic Healthcare Professionals.
Healthcare Professional Tools
Maternal PKU - A Quick Guide and Practical Tips for Healthcare Professionals
A quick guide and practical tips on how to manage maternal PKU.
Monogen Dilution Chart
This resource has been developed for use by Healthcare Professionals. It includes recipes for mixing Monogen at multiple dilutions (from 20 to 30 calories per fluid ounce), as well as household measures.
Evolution of Nutricia Portfolio – Product Transitioning Tools
As you begin to transition your patients from the Maxamaid and Milupa products, we have created transition tools to help you identify alternative products.
Metabolic Product Poster
A quick-glance poster of Nutricia's full product portfolio for both PKU and rare metabolic disorders. Products are categorized based on indication along with their appropriate age groups.
Approximate US household measurements available for the following products:
Early Years Interactive Tools
The Early Years interactive transition tools aid healthcare professionals with calculations to help transition infants from the Periflex/Anamix Early Years to the next stage formulas (Anamix Next/Periflex Junior Plus) for ages 1+.
- GA1 Anamix Early Years to GlutarAde Essential
- HCU Anamix Early Years to HCU Anamix Next
- IVA Anamix Early Years to IVA Anamix Next
- MMA/PA Anamix Early Years to MMA/PA Anamix Next
- MSUD Anamix Early Years to Complex Essential
- PKU Periflex Early Years to PKU Periflex Junior Plus
- TYR Anamix Early Years to TYR Anamix Next
TYR Anamix® Next Resources
TYR Anamix Next Resources to aid healthcare professionals with calculations when transitioning patients to this advanced formula with DHA & Fiber.
Vademecum Metabolicum—Diagnosis and Treatment of Inborn Errors of Metabolism (J. Zschocke, GF Hoffmann; Schattauer)
A booklet with the objective of providing a systematic approach to the diagnosis of metabolic disease. It also contains guidelines for optimal therapy to aid in the management of genetic diseases of metabolism. The 3rd edition is available compliments of Nutricia North America.
- To obtain the booklet, please e-mail NutritionServices@nutricia.com
PKU Periflex® Junior Plus Transition Resources
PKU Periflex Junior Plus Transition Resources to aid healthcare professionals with calculations when transitioning patients to this advanced formula with DHA & Fiber.
Sample Request Links
Request samples for your patients or clinic.
Metabolic Interactive Tools
These are interactive tools for Healthcare Professionals to help calculate the amount of Nutricia metabolic product needed to achieve a desired amount of protein equivalent for individual patients. The tool can then be used to compare macro and micro nutrients to the DRIs (as of 2010). (Microsoft® Excel files - note, please right click on the link and “Save Target As...” to save this to your desktop and then open through Excel).
Prescriber’s Guide to Duocal
A Prescriber’s Guide to Duocal, a medical food providing calories in form of fat and carbohydrate. This resource outlines guidelines on how to use and how much to prescribe for your patients.
Product Authorization Form
Use this consent form when ordering Nutricia metabolic product samples for your patients.
Eat Right-Stay Bright
An anticipatory guidance tool, developed by The Children's Hospital of Colorado, Denver, to aid healthcare professionals in the treatment of patients with PKU. Materials and topics include: Clinic Encounter Check Lists, Experience and Thoughts, Teaching Aids and Handouts and other resources. All chapters have been developed as an anticipatory guidance tool with patient education and improved patient compliance as its main goal. We welcome you to print, individualize, and add to any and all of the sections. Whatever your approach, we hope this educational tool assists you in your clinic setting.
Guidelines for the Usage of PhenylAde PheBLOC
Practical guidelines on how to incorporate PhenylAde PheBLOC, a medical food containing large neutral amino acids, into the PKU diet.
Guidelines for the Nutritional Management of Tyrosinemia
A Practical Guide for the Use of Nutricia's TYR Products. This guide provides an overview of TYR, discusses basic diet principles, and monitoring parameters.
Nutrition Assessment Guidelines
This section includes general guidelines for monitoring effect of nutrition intervention in many different metabolic disorders.
Guidelines to managing acute illness in patients with specific inborn errors
Summary of major biochemical features and emergency treatments for various metabolic disorders.
Recommended Nutrient Intakes
A list of recommended intakes for initiating and managing nutrition therapy in selected patients with inborn errors.
Guidelines for the Nutritional Management of Maple Syrup Urine Disease
A Practical Guide for the Use of Nutricia's MSUD Products
Guidelines for Management of Urea Cycle Disorders: A Practical Guide for the use of UCD Anamix Junior
A practical guide for the use of UCD Anamix Junior in the dietary management of UCD. The guide provides an overview of UCD, discusses basic diet principles, monitoring parameters as well as case studies.
Guidelines for the Use of Lanaflex in the Dietary Management of Phenylketonuria
Practical guidelines on how to incorporate Lanaflex, a medical food containing large neutral amino acids and micronutrients, into the PKU diet. The guide provides an introduction and background discussion of the concept of large neutral amino acids as well as flow charts on how to use Lanaflex alone or in combination with a traditional PKU diet.
Clinical References for Periflex® Infant
- Agostoni C et al. A randomized trial of long-chain polyunsaturated fatty acid supplementation in infants with phenylketonuria. Dev Med Child Neurol. 2006;48(3):207-12. PubMed
- Greve LC et al. Breast-Feeding in the Management of the Newborn with Phenylketonuria: A Practical Approach to Dietary Therapy. J Am Diet Assoc. 1994;94(3):305-9. PubMed
- Mofidi et al. Growth And Plasma Phenylalanine And Tyrosine Concentrations Of Infants Treated With XPhe Analog Amino Acid Modified Infant Formula With Iron. Presented at the V International Congress of Inborn Errors of Metabolism, June 1-5, 1990.
- Various authors. A Multicentre Study to Evaluate and Compare the Nutritional Adequacy of XP Analog and Lofenalac in the Dietary Management of Infants with Phenylketonuria (PKU). (1986-1989). Data on file.
Clinical References for Periflex® Junior
- Cleary MA et al. Randomised controlled trial of essential fatty acid supplementation in phenylketonuria. Eur J Clin Nutr. 2006;60(7):915-20. PubMed
- Rose HJ. Fat intakes of children with PKU on low phenylalanine diets. J Hum Nutr Diet. 2005;18(5):395-400. PubMed
- Buist NRM et al. A new amino acid mixture permits new approaches to the treatment of phenylketonuria. Acta Paediatr Suppl. 1994;407:75-7. PubMed
Clinical References for XPhe Maxamaid®
- MacDonald A et al. Factors Affecting the Variation in Plasma Phenylalanine in Patients with Phenylketonuria on Diet. Arch Dis Child. 1996; 74: 412-417. PubMed
- MacDonald A et al. Feeding Problems in Young PKU Children. Acta Paediatr. 1994; 407: (Suppl) 73-74. PubMed
- MacDonald A. Diet and Phenylketonuria: A Time for Change? J Hum Nutr Diet. 1994; 7:105-114.
- Clinical evaluation report 1980-1982 by Prof. Frezal, Sick Children’s Hospital Paris, available upon request.
- Clinical evaluation report Dr. Sardhawalla, Royal Manchester Children’s Hospital, available upon request.
Clinical References for XPhe Maxamum®
- Brown MC, et al Economic impact of feeding a phenylalanine-restricted diet to adults with previously untreated phenylketonuria. J Intell Disabil Res. 1999; 43:30-7. PubMed
- Cleary MA, et al. Magnetic Resonance Imaging in Phenylketonuria: Reversal of Cerebral White Matter Change. J Pediatr. 1995; 127:251-255. PubMed
- MacDonald A. Diet and Phenylketonuria: Time for Change? J Hum Nutr Diet. 1994; 7:105-114.
- Wardley BL & Taitz LS Clinical Trial of a Concentrated Amino Acid Formula for Older Patients with Phenylketouria (XP Maxamum). Eur J Clin Nutr. 1988; 42:81-86.
- Taitz LS, et al. Zinc and Selenium Levels in Older Children with Phenylketonuria – Correction of Low Plasma Levels by a New Dietary Supplement Formulation (XP Maxamum). Data on file.
XPhe Maxamum Drink (Renamed Periflex LQ in 2014)
Clinical References for XPhe Maxamum Drink (Renamed Periflex LQ in 2014).
- Shaw H, Yannicelli S. Acceptability and Clinical use of a new Ready-To-Drink PKU product. Poster presented at annual meeting of GMDI (Genetic Metabolic Dietitians International), Atlanta, USA, 2006.
Clinical References for Lanaflex®
- Schindeler S et al. The effects of large neutral amino acids supplements in PKU: An MRS and neuropsychological study. Mol Gen and Metab 2007; 91:48-54. PubMed
- Crowley C et at. Clinical trial of “off diet” older phenylketonurics with a new phenylalanine-free product. J Metal Deficiency Research 1990; 34: 361-369. PubMed
Clinical References for Monogen®
- Lessen R. Use of Skim Breast Milk for an Infant with Chylothorax. ICAN (2009); 1 (6):303-10
- Ficicioglu C, et al. Very long-chain acyl-CoA dehydrogenase deficiency : The effects of accidental fat loading in a a patient detected through newborn screening. J Inherit Metab Dis. 2009 Apr 4 (Epub ahead of print). PubMed
- Izzard, ME et al. The use of Monogen on the conservative management of chylous fistula. Otolaryng Head Neck. 2007;136 (4 Suppl): S50-3. PubMed
- Möller A, et al. Congenital intestinal lymphangiectasia: a rare differential diagnosis in hypoproteinemia in infants. Klin Padiatrie. 2006;218(4):224-5 (German). PubMed
- Cormack, BE et al. Use of Monogen for pediatric postoperative chylothorax. Ann Thorac Surg. 2004; 77(1):301-5. PubMed
- Ng, PC et al. Deceptive hyperbilirubinaemia in a newborn with familial lipoprotein lipase deficiency. J Paediatr Child H. 2001;37(3):314-6. PubMed
Clinical References for Duocal®
- Illsinger S, Lücke T, Meyer U, Vaske B, Das AM. Branched chain amino acids as a parameter for catabolism in treated phenylketonuria. Amino Acids. 2005 Feb;28(1):45-50. PubMed
- Plauth M, Roske AE, Romaniuk P, Roth E, Ziebig R, Lochs H. Post-feeding hyperammonaemia in patients with transjugular intrahepatic portosystemic shunt and liver cirrhosis: role of small intestinal ammonia release and route of nutrient administration. Gut. 2000 Jun;46(6):849-55. PubMed
- Wilson DC, Cairns P, Halliday HL, Reid M, McClure G, Dodge JA. Randomised controlled trial of an aggressive nutritional regimen in sick very low birthweight infants. Arch Dis Child Fetal Neonatal Ed. 1997 Jul;77(1):F4-11. PubMed
- Iacona G Carroccio A, Cavataio F & Montalto G. Case report: Multiple food allergy. J Pediatr Gastroenterol Nutr 1993; 16:472-473
- Morris R, Hart K, Smith V, Shannon L, Bolton J, Abbott R, Alleyne M, Plant H, Slevin ML. A comparison of the energy supplements Polycal and Duocal in cancer patients. J Hum Nutr Diet. 1990; 3: 171-176